The Mga Regulon but Not Deoxyribonuclease Sda1 of Invasive M1T1 Group A Streptococcus Contributes to In Vivo Selection of CovRS Mutations and Resistance to Innate Immune Killing Mechanisms

Invasive M1T1 group A Streptococcus (GAS) can have a mutation in the regulatory system CovRS, and this mutation can render strains hypervirulent. Interestingly, via mechanisms that are not well understood, the host innate immune system's neutrophils select spontaneous M1T1 GAS CovRS hypervirule...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Liu, Guanghui, Feng, Wenchao, Li, Dengfeng, Liu, Mengyao, Nelson, Daniel C., Lei, Benfang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598402/
https://ncbi.nlm.nih.gov/pubmed/26283338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00857-15
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