HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators

Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA. In HIV-1 the protease, reverse transcriptase, and integrase enzymes are in a second reading frame relative to the structural group-s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Cardno, Tony S., Shimaki, Yosuke, Sleebs, Brad E., Lackovic, Kurt, Parisot, John P., Moss, Rebecca M., Crowe-McAuliffe, Caillan, Mathew, Suneeth F., Edgar, Christina D., Kleffmann, Torsten, Tate, Warren P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598141/
https://ncbi.nlm.nih.gov/pubmed/26447468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139036
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