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How do oncoprotein mutations rewire protein-protein interaction networks? Perspectives and techniques

The acquisition of mutations that activate oncogenes or inactivate tumour suppressors is a primary feature of most cancers. Mutations that directly alter protein sequence and structure drive the development of tumours through aberrant expression and modification of proteins, in many cases directly i...

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Dades bibliogràfiques
Publicat a:Expert Rev Proteomics
Autors principals: Bowler, Emily, Wang, Zhenghe, Ewing, Rob M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598059/
https://ncbi.nlm.nih.gov/pubmed/26325016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/14789450.2015.1084875
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