Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability

Choroidal neovascularization (CNV) is a defining feature of wet age-related macular degeneration. We examined the functional role of CCR3 in the development of CNV in mice and primates. CCR3 was associated with spontaneous CNV lesions in the newly described JR5558 mice, whereas CCR3 ligands localize...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Nagai, Nori, Ju, Meihua, Izumi-Nagai, Kanako, Robbie, Scott J., Bainbridge, James W., Gale, David C., Pierre, Esaie, Krauss, Achim H.P., Adamson, Peter, Shima, David T., Ng, Yin-Shan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597271/
https://ncbi.nlm.nih.gov/pubmed/26188133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.04.029
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