Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength

Ca(2+)-sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent io...

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Publicat a:Nat Struct Mol Biol
Autors principals: Park, Yongsoo, Seo, Jong Bae, Fraind, Alicia, Pérez-Lara, Angel, Yavuz, Halenur, Han, Kyungreem, Jung, Seung-Ryoung, Kattan, Iman, Walla, Peter Jomo, Choi, MooYoung, Cafiso, David S., Koh, Duk-Su, Jahn, Reinhard
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596797/
https://ncbi.nlm.nih.gov/pubmed/26389740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3097
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