Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength

Ca(2+)-sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent io...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Park, Yongsoo, Seo, Jong Bae, Fraind, Alicia, Pérez-Lara, Angel, Yavuz, Halenur, Han, Kyungreem, Jung, Seung-Ryoung, Kattan, Iman, Walla, Peter Jomo, Choi, MooYoung, Cafiso, David S., Koh, Duk-Su, Jahn, Reinhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596797/
https://ncbi.nlm.nih.gov/pubmed/26389740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3097
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge