Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength

Ca(2+)-sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent io...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Park, Yongsoo, Seo, Jong Bae, Fraind, Alicia, Pérez-Lara, Angel, Yavuz, Halenur, Han, Kyungreem, Jung, Seung-Ryoung, Kattan, Iman, Walla, Peter Jomo, Choi, MooYoung, Cafiso, David S., Koh, Duk-Su, Jahn, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596797/
https://ncbi.nlm.nih.gov/pubmed/26389740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3097
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