Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

The Alanine-Serine-Cysteine transporter ASCT2 (SLC1A5) is a membrane protein that transports neutral amino acids into cells in exchange for outward movement of intracellular amino acids. ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where it contributes to the homeo...

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Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Colas, Claire, Grewer, Christof, Otte, Nicholas James, Gameiro, Armanda, Albers, Thomas, Singh, Kurnvir, Shere, Helen, Bonomi, Massimiliano, Holst, Jeff, Schlessinger, Avner
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596572/
https://ncbi.nlm.nih.gov/pubmed/26444490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004477
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