Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors

Antibody-dependent cellular cytotoxicity (ADCC) is an important effector function determining the clinical efficacy of therapeutic antibodies. Core fucose removal from N-glycans on the Fc portion of immunoglobulin G (IgG) improves the binding affinity for Fcγ receptor IIIa (FcγRIIIa) and dramaticall...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS One
Hlavní autoři: Isoda, Yuya, Yagi, Hirokazu, Satoh, Tadashi, Shibata-Koyama, Mami, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi, Iida, Shigeru
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596520/
https://ncbi.nlm.nih.gov/pubmed/26444434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140120
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky