Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition

BACKGROUND: Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the malignant progression of RMS, especially in the alveolar subtype. This observati...

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Detalles Bibliográficos
Publicado en:J Exp Clin Cancer Res
Main Authors: Megiorni, Francesca, McDowell, Heather P., Camero, Simona, Mannarino, Olga, Ceccarelli, Simona, Paiano, Milena, Losty, Paul D., Pizer, Barry, Shukla, Rajeev, Pizzuti, Antonio, Clerico, Anna, Dominici, Carlo
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596370/
https://ncbi.nlm.nih.gov/pubmed/26445453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0228-4
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