Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies

An attractive approach for designing lead antibody candidates is to mimic natural protein interactions by grafting peptide recognition motifs into the complementarity-determining regions (CDRs). We are using this approach to generate single-domain (V(H)) antibodies specific for amyloid-forming prote...

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Dettagli Bibliografici
Pubblicato in:Protein Eng Des Sel
Autori principali: Julian, Mark C., Lee, Christine C., Tiller, Kathryn E., Rabia, Lilia A., Day, Evan K., Schick, Arthur J., Tessier, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Single Domain Antibodies, Libraries and Innovations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596281/
https://ncbi.nlm.nih.gov/pubmed/26386257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv050
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