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Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies
An attractive approach for designing lead antibody candidates is to mimic natural protein interactions by grafting peptide recognition motifs into the complementarity-determining regions (CDRs). We are using this approach to generate single-domain (V(H)) antibodies specific for amyloid-forming prote...
Gespeichert in:
| Veröffentlicht in: | Protein Eng Des Sel |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4596281/ https://ncbi.nlm.nih.gov/pubmed/26386257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv050 |
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