Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion(1,2,3)

Calcium-permeable transient receptor potential M2 (TRPM2) ion channel activation contributes to cerebral ischemic injury specifically in males. In male mice, circulating androgens are required for TRPM2 inhibition with clotrimazole (CTZ) to provide protection following experimental stroke. Sufficien...

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Pubblicato in:eNeuro
Autori principali: Quillinan, Nidia, Grewal, Himmat, Klawitter, Jelena, Herson, Paco S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2014
Soggetti:
Disorders of the Nervous System
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596140/
https://ncbi.nlm.nih.gov/pubmed/26464961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0022-14.2014
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