Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia

Motor deficits are present in cardiac arrest survivors and injury to cerebellar Purkinje cells (PCs) likely contribute to impairments in motor coordination and post-hypoxic myoclonus. NMDA receptor mediated excitotoxicity is a well-established mechanism of cell death in several brain regions, but th...

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Pubblicato in:Neuroscience
Autori principali: Quillinan, Nidia, Grewal, Himmat, Deng, Guiying, Shimizu, Kaori, Yonchek, Joan C, Strnad, Frank, Traystman, Richard J, Herson, Paco S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268020/
https://ncbi.nlm.nih.gov/pubmed/25450957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.10.033
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