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Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels

OBJECTIVE: Sirtuins (Sirt) are a class of deacetylase enzymes that play an important role in cell proliferation. Sirt2 activation produces O-acetylated-ADPribose (OAADPr) which can act as a ligand for transient receptor potential cation channel, M2 (TRPM2). We tested the hypothesis that Sirt2 is act...

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Bibliographische Detailangaben
Veröffentlicht in:Exp Neurol
Hauptverfasser: Shimizu, Kaori, Quillinan, Nidia, Orfila, James E., Herson, Paco S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193101/
https://ncbi.nlm.nih.gov/pubmed/26522013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.10.014
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