Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity

Herein is a first effort to systematically study the significance of carbon-sulfur (C-S) and carbon-amine (C-NH) bonds on the antitumor proliferation activity of podophyllum derivatives and their precise mechanism of apoptosis. Compared with the derivative modified by a C-NH bond, the derivative mod...

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Publicado no:Sci Rep
Main Authors: Li, Jian-Long, Zhao, Wei, Zhou, Chen, Zhang, Ya-Xuan, Li, Hong-Mei, Tang, Ya-Ling, Liang, Xin-Hua, Chen, Tao, Tang, Ya-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595834/
https://ncbi.nlm.nih.gov/pubmed/26443888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14814
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