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Methemoglobin Formation and Characterization Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines
Arylamines (AA) and heterocyclic aromatic amines (HAA) are structurally related carcinogens formed during combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and lead to mutations. The N-hydroxylated metabolites of man...
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| Pubblicato in: | Chem Res Toxicol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801648/ https://ncbi.nlm.nih.gov/pubmed/26824300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00418 |
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