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Methemoglobin Formation and Characterization Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines

Arylamines (AA) and heterocyclic aromatic amines (HAA) are structurally related carcinogens formed during combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and lead to mutations. The N-hydroxylated metabolites of man...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Pathak, Khyatiben V., Chiu, Ting-Lan, Amin, Elizabeth Ambrose, Turesky, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801648/
https://ncbi.nlm.nih.gov/pubmed/26824300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00418
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