Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

Molecular targeted drugs are clinically effective anti-cancer therapies. However, tumours treated with single agents usually develop resistance. Here we use colorectal cancer (CRC) as a model to study how the acquisition of resistance to EGFR-targeted therapies can be restrained. Pathway-oriented ge...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Misale, Sandra, Bozic, Ivana, Tong, Jingshan, Peraza-Penton, Ashley, Lallo, Alice, Baldi, Federica, Lin, Kevin H., Truini, Mauro, Trusolino, Livio, Bertotti, Andrea, Di Nicolantonio, Federica, Nowak, Martin A., Zhang, Lin, Wood, Kris C., Bardelli, Alberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595628/
https://ncbi.nlm.nih.gov/pubmed/26392303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9305
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