Biodistribution and Pharmacokinetic Studies of Bone-Targeting N-(2-Hydroxypropyl)methacrylamide Copolymer–Alendronate Conjugates

The biodistribution and pharmacokinetics of bone-targeting N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer–alendronate conjugates were evaluated following intravenous administration of radioiodinated conjugates to young healthy BALB/c mice. The synthesis of a polymerizable and cathepsin K cleava...

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Publicado en:Mol Pharm
Autores principales: Pan, Huaizhong, Sima, Monika, Kopečková, Pavla, Wu, Kuangshi, Gao, Songqi, Liu, Jihua, Wang, Dong, Miller, Scott C., Kopeček, Jindřich
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595038/
https://ncbi.nlm.nih.gov/pubmed/18505266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800003u
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