Backbone Degradable Multiblock N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates via Reversible Addition Fragmentation Chain Transfer Polymerization and Thiol-ene Coupling Reaction

Telechelic water-soluble HPMA copolymers and HPMA copolymer-doxorubicin (DOX) conjugates have been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA) that contains an enzymatically degradable oligopeptide sequence. Post-polymerization aminolysis followed by...

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Bibliographic Details
Main Authors: Pan, Huaizhong, Yang, Jiyuan, Kopečková, Pavla, Kopeček, Jindřich
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025662/
https://ncbi.nlm.nih.gov/pubmed/21158387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm101254e
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