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Microtubules negatively regulate insulin secretion in pancreatic β cells
For glucose-stimulated insulin secretion (GSIS) insulin granules have to be localized close to the plasma membrane. The role of microtubule-dependent transport in granule positioning and GSIS has been debated. Here, we report that microtubules, counterintuitively, restrict granule availability for s...
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| Publicado en: | Dev Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594944/ https://ncbi.nlm.nih.gov/pubmed/26418295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.020 |
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