Microtubules negatively regulate insulin secretion in pancreatic β cells

For glucose-stimulated insulin secretion (GSIS) insulin granules have to be localized close to the plasma membrane. The role of microtubule-dependent transport in granule positioning and GSIS has been debated. Here, we report that microtubules, counterintuitively, restrict granule availability for s...

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Udgivet i:Dev Cell
Main Authors: Zhu, Xiaodong, Hu, Ruiying, Brissova, Marcela, Stein, Roland W., Powers, Alvin C., Gu, Guoqiang, Kaverina, Irina
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594944/
https://ncbi.nlm.nih.gov/pubmed/26418295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.020
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