Microtubules negatively regulate insulin secretion in pancreatic β cells

For glucose-stimulated insulin secretion (GSIS) insulin granules have to be localized close to the plasma membrane. The role of microtubule-dependent transport in granule positioning and GSIS has been debated. Here, we report that microtubules, counterintuitively, restrict granule availability for s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Zhu, Xiaodong, Hu, Ruiying, Brissova, Marcela, Stein, Roland W., Powers, Alvin C., Gu, Guoqiang, Kaverina, Irina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594944/
https://ncbi.nlm.nih.gov/pubmed/26418295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.020
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