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Regulation of glucose-dependent Golgi-derived microtubules by cAMP/EPAC2 promotes secretory vesicle biogenesis in pancreatic β-cells
The microtubule (MT) network is an essential regulator of insulin secretion from pancreatic β-cells, which is central to blood-sugar homeostasis. We find that glucose metabolism induces insulin secretion but also increases formation of Golgi-derived microtubules (GDMTs), notably with the same biphas...
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| Veröffentlicht in: | Curr Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698911/ https://ncbi.nlm.nih.gov/pubmed/31303487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.06.032 |
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