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Regulation of glucose-dependent Golgi-derived microtubules by cAMP/EPAC2 promotes secretory vesicle biogenesis in pancreatic β-cells

The microtubule (MT) network is an essential regulator of insulin secretion from pancreatic β-cells, which is central to blood-sugar homeostasis. We find that glucose metabolism induces insulin secretion but also increases formation of Golgi-derived microtubules (GDMTs), notably with the same biphas...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Trogden, Kathryn P., Zhu, Xiaodong, Lee, Justin S., Wright, Christopher V.E., Gu, Guoqiang, Kaverina, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698911/
https://ncbi.nlm.nih.gov/pubmed/31303487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.06.032
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