The Legionella anti-autophagy effector RavZ targets the autophagosome via PI3P- and curvature-sensing motifs

Autophagy is a conserved membrane transport pathway used to destroy pathogenic microbes that access the cytosol of cells. The intracellular pathogen Legionella pneumophila interferes with autophagy by delivering an effector protein, RavZ, into the host cytosol. RavZ acts by cleaving membrane-conjuga...

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Udgivet i:Dev Cell
Main Authors: Horenkamp, Florian A., Kauffman, Karlina J., Kohler, Lara J., Sherwood, Racquel K., Krueger, Kathryn P., Shteyn, Vladimir, Roy, Craig R., Melia, Thomas J., Reinisch, Karin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594837/
https://ncbi.nlm.nih.gov/pubmed/26343456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.010
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