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The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

Eukaryotic cells can use the autophagy pathway to defend against microbes that gain access to the cytosol or reside in pathogen-modified vacuoles. It remains unclear if pathogens have evolved specific mechanisms to manipulate autophagy. Here we find that the intracellular pathogen Legionella pneumop...

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Autors principals: Choy, Augustine, Dancourt, Julia, Mugo, Brian, O'Connor, Tamara J., Isberg, Ralph R., Melia, Thomas J., Roy, Craig R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682818/
https://ncbi.nlm.nih.gov/pubmed/23112293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227026
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