Opposite malaria and pregnancy effect on oral bioavailability of artesunate – a population pharmacokinetic evaluation

AIM: The aim was to compare the pharmacokinetic properties of artesunate and dihydroartemisinin in the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregnant with convalescent malaria on day 7 and iii) in a healthy state 3 months post-partum on day 1, 2 and 7. METHODS:...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Kloprogge, Frank, McGready, Rose, Phyo, Aung Pyae, Rijken, Marcus J, Hanpithakpon, Warunee, Than, Hla Hla, Hlaing, Nathar, Zin, Naw Thida, Day, Nicholas P J, White, Nicholas J, Nosten, François, Tarning, Joel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594700/
https://ncbi.nlm.nih.gov/pubmed/25877779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12660
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