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Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies
The p.I141V mutation of the voltage-gated sodium channel is associated with several clinical hyper-excitability phenotypes. To understand the structural bases of the p.I141V biophysical alterations, molecular dynamics simulations were performed. These simulations predicted that the p.I141V substitut...
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| Publicado no: | Channels (Austin) |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594541/ https://ncbi.nlm.nih.gov/pubmed/25483584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336950.2014.958922 |
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