Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins

We developed and optimized a high-throughput project workflow to generate renewable recombinant antibodies to human proteins involved in epigenetic signalling. Three different strategies to produce phage display compatible protein antigens in bacterial systems were compared, and we found that in viv...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhong, Nan, Loppnau, Peter, Seitova, Alma, Ravichandran, Mani, Fenner, Maria, Jain, Harshika, Bhattacharya, Anandi, Hutchinson, Ashley, Paduch, Marcin, Lu, Vincent, Olszewski, Michal, Kossiakoff, Anthony A., Dowdell, Evan, Koide, Akiko, Koide, Shohei, Huang, Haiming, Nadeem, Vincent, Sidhu, Sachdev S., Greenblatt, Jack F., Marcon, Edyta, Arrowsmith, Cheryl H., Edwards, Aled M., Gräslund, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593582/
https://ncbi.nlm.nih.gov/pubmed/26437229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139695
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