Withaferin A Analogs That Target the AAA+ Chaperone p97

Understanding the mode of action (MOA) of many natural products can be puzzling with mechanistic clues that seem to lack a common thread. One such puzzle lies in the evaluation of the antitumor properties of the natural product withaferin A (WFA). A variety of seemingly unrelated pathways have been...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Tao, Shasha, Tillotson, Joseph, Wijeratne, E. M. Kithsiri, Xu, Ya-ming, Kang, MinJin, Wu, Tongde, Lau, Eric C., Mesa, Celestina, Mason, Damian J., Brown, Robert V., Clair, James J. La, Gunatilaka, A. A. Leslie, Zhang, Donna D., Chapman, Eli
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593394/
https://ncbi.nlm.nih.gov/pubmed/26006219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00367
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