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Inhibitors of the AAA+ Chaperone p97

It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat refractory myeloma and later extended to lymphoma. Its...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Chapman, Eli, Maksim, Nick, de la Cruz, Fabian, La Clair, James J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576884/
https://ncbi.nlm.nih.gov/pubmed/25685910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20023027
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