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Inhibitors of the AAA+ Chaperone p97

It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat refractory myeloma and later extended to lymphoma. Its...

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Vydáno v:Molecules
Hlavní autoři: Chapman, Eli, Maksim, Nick, de la Cruz, Fabian, La Clair, James J.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576884/
https://ncbi.nlm.nih.gov/pubmed/25685910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20023027
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