Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action

Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we have developed a system that uses discreet, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this funct...

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Main Authors: Kang, MinJin, Wu, Tongde, Wijeratne, E. M. Kithsiri, Lau, Eric C., Mason, Damian J., Mesa, Celestina, Tillotson, Joseph, Zhang, Donna D., Gunatilaka, A. A. Leslie, La Clair, James J., Chapman, Eli
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187115/
https://ncbi.nlm.nih.gov/pubmed/25125376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402258
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