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Non-covalent NRF2 Activation Confers Greater Cellular Protection Than Covalent Activation
The transcription factor NRF2 confers cellular protection by maintaining cellular redox homeostasis and proteostasis. Basal NRF2 levels are normally low due to KEAP1-mediated ubiquitylation and subsequent proteasomal degradation. KEAP1, a substrate adaptor protein of a KEAP1-CUL3-RBX1 E3 ubiquitin l...
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| Publicado no: | Cell Chem Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800637/ https://ncbi.nlm.nih.gov/pubmed/31402317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.011 |
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