Non-covalent NRF2 Activation Confers Greater Cellular Protection Than Covalent Activation

The transcription factor NRF2 confers cellular protection by maintaining cellular redox homeostasis and proteostasis. Basal NRF2 levels are normally low due to KEAP1-mediated ubiquitylation and subsequent proteasomal degradation. KEAP1, a substrate adaptor protein of a KEAP1-CUL3-RBX1 E3 ubiquitin l...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Chem Biol
Main Authors: Liu, Pengfei, Tian, Wang, Tao, Shasha, Tillotson, Joseph, Wijeratne, E. M. Kithsiri, Gunatilaka, A. A. Leslie, Zhang, Donna D., Chapman, Eli
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800637/
https://ncbi.nlm.nih.gov/pubmed/31402317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.011
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