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Non-covalent NRF2 Activation Confers Greater Cellular Protection Than Covalent Activation

The transcription factor NRF2 confers cellular protection by maintaining cellular redox homeostasis and proteostasis. Basal NRF2 levels are normally low due to KEAP1-mediated ubiquitylation and subsequent proteasomal degradation. KEAP1, a substrate adaptor protein of a KEAP1-CUL3-RBX1 E3 ubiquitin l...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Chem Biol
Egile Nagusiak: Liu, Pengfei, Tian, Wang, Tao, Shasha, Tillotson, Joseph, Wijeratne, E. M. Kithsiri, Gunatilaka, A. A. Leslie, Zhang, Donna D., Chapman, Eli
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800637/
https://ncbi.nlm.nih.gov/pubmed/31402317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.011
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