CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex

A key point to regulate gene expression is at transcription initiation, and activators play a major role. CarD, an essential activator in Mycobacterium tuberculosis, is found in many bacteria, including Thermus species, but absent in Escherichia coli. To delineate the molecular mechanism of CarD, we...

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Bibliographic Details
Published in:eLife
Main Authors: Bae, Brian, Chen, James, Davis, Elizabeth, Leon, Katherine, Darst, Seth A, Campbell, Elizabeth A
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593161/
https://ncbi.nlm.nih.gov/pubmed/26349034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08505
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