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DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates
DEL-1 is an endothelial cell-secreted protein that regulates LFA-1-integrin–dependent leukocyte recruitment and inflammation in various tissues. Here we identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteocla...
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| Veröffentlicht in: | Sci Transl Med |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593066/ https://ncbi.nlm.nih.gov/pubmed/26424570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac5380 |
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