DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

DEL-1 is an endothelial cell-secreted protein that regulates LFA-1-integrin–dependent leukocyte recruitment and inflammation in various tissues. Here we identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteocla...

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Udgivet i:Sci Transl Med
Main Authors: Shin, Jieun, Maekawa, Tomoki, Abe, Toshiharu, Hajishengallis, Evlambia, Hosur, Kavita, Pyaram, Kalyani, Mitroulis, Ioannis, Chavakis, Triantafyllos, Hajishengallis, George
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593066/
https://ncbi.nlm.nih.gov/pubmed/26424570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac5380
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