Difluoromethyl ketones: potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

Malaria is a devastating disease in sub-Saharan Africa, and current vector control measures are threatened by emerging resistance mechanisms. With the goal of developing new, selective, resistance-breaking insecticides we explored α-fluorinated methyl ketones as reversible covalent inhibitors of Ano...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Camerino, Eugene, Wong, Dawn M., Tong, Fan, Körber, Florian, Gross, Aaron D., Islam, Rafique, Viayna, Elisabet, Mutunga, James M., Li, Jianyong, Totrov, Maxim M., Bloomquist, Jeffrey R., Carlier, Paul R.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593063/
https://ncbi.nlm.nih.gov/pubmed/26386602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.09.019
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires