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Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers

Chemical allergens bind directly, or after metabolic or abiotic activation, to endogenous proteins to become allergenic. Assessment of this initial binding has been suggested as a target for development of assays to screen chemicals for their allergenic potential. Recently we reported a nitrobenzene...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Toxicology
Hauptverfasser: Chipinda, Itai, Mbiya, Wilbes, Adigun, Risikat Ajibola, Morakinyo, Moshood K., Law, Brandon F., Simoyi, Reuben H., Siegel, Paul D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593055/
https://ncbi.nlm.nih.gov/pubmed/24333919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2013.11.009
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