Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid

We recently reported the synthesis of NOSH-aspirin, a novel hybrid compound capable of releasing both nitric oxide (NO) and hydrogen sulfide (H(2)S). In NOSH-aspirin, the two moieties that release NO and H(2)S are covalently linked at the 1, 2 positions of acetyl salicylic acid, i.e. ortho-NOSH-aspi...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Vannini, Federica, MacKessack-Leitch, Andrew C., Eschbach, Erin K., Chattopadhyay, Mitali, Kodela, Ravinder, Kashfi, Khosrow
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592841/
https://ncbi.nlm.nih.gov/pubmed/26323873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.023
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