A cell-based model system links chromothripsis with hyperploidy

A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to lack of suitable model systems, the mechanistic basis of chromothripsis has...

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Publicat a:Mol Syst Biol
Autors principals: Mardin, Balca R, Drainas, Alexandros P, Waszak, Sebastian M, Weischenfeldt, Joachim, Isokane, Mayumi, Stütz, Adrian M, Raeder, Benjamin, Efthymiopoulos, Theocharis, Buccitelli, Christopher, Segura-Wang, Maia, Northcott, Paul, Pfister, Stefan M, Lichter, Peter, Ellenberg, Jan, Korbel, Jan O
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592670/
https://ncbi.nlm.nih.gov/pubmed/26415501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20156505
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