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Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library
Multiple mechanisms exist for endocrine disruption; one nonreceptor-mediated mechanism is via effects on aromatase, an enzyme critical for maintaining the normal in vivo balance of androgens and estrogens. We adapted the AroER tri-screen 96-well assay to 1536-well format to identify potential aromat...
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| 出版年: | Toxicol Sci |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4592355/ https://ncbi.nlm.nih.gov/pubmed/26141389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv141 |
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