Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library

Multiple mechanisms exist for endocrine disruption; one nonreceptor-mediated mechanism is via effects on aromatase, an enzyme critical for maintaining the normal in vivo balance of androgens and estrogens. We adapted the AroER tri-screen 96-well assay to 1536-well format to identify potential aromat...

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Veröffentlicht in:Toxicol Sci
Hauptverfasser: Chen, Shiuan, Hsieh, Jui-Hua, Huang, Ruili, Sakamuru, Srilatha, Hsin, Li-Yu, Xia, Menghang, Shockley, Keith R., Auerbach, Scott, Kanaya, Noriko, Lu, Hannah, Svoboda, Daniel, Witt, Kristine L., Merrick, B. Alex, Teng, Christina T., Tice, Raymond R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
High Throughput Testing of Aromatase Inhibition
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592355/
https://ncbi.nlm.nih.gov/pubmed/26141389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv141
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