FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

The Fanconi anemia (FA)-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex). However, the regulation of t...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Castella, Maria, Jacquemont, Celine, Thompson, Elizabeth L., Yeo, Jung Eun, Cheung, Ronald S., Huang, Jen-Wei, Sobeck, Alexandra, Hendrickson, Eric A., Taniguchi, Toshiyasu
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592014/
https://ncbi.nlm.nih.gov/pubmed/26430909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005563
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