Fibroblast-derived Neuregulin 1 Promotes Compensatory ErbB3 Receptor Signaling in Mutant BRAF Melanoma

Rapidly accelerated fibrosarcoma (RAF) inhibitors are first-line treatments for patients harboring V600E/K mutant BRAF melanoma. Although RAF inhibitors produce high response rates, the degree of tumor regression is heterogeneous. Compensatory/adaptive responses to targeted inhibitors are frequently...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Capparelli, Claudia, Rosenbaum, Sheera, Berger, Adam C., Aplin, Andrew E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591813/
https://ncbi.nlm.nih.gov/pubmed/26269601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657270
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