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Fibroblast-derived Neuregulin 1 Promotes Compensatory ErbB3 Receptor Signaling in Mutant BRAF Melanoma

Rapidly accelerated fibrosarcoma (RAF) inhibitors are first-line treatments for patients harboring V600E/K mutant BRAF melanoma. Although RAF inhibitors produce high response rates, the degree of tumor regression is heterogeneous. Compensatory/adaptive responses to targeted inhibitors are frequently...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Capparelli, Claudia, Rosenbaum, Sheera, Berger, Adam C., Aplin, Andrew E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591813/
https://ncbi.nlm.nih.gov/pubmed/26269601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657270
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