Unifying the DNA End-processing Roles of the Artemis Nuclease: KU-DEPENDENT ARTEMIS RESECTION AT BLUNT DNA ENDS

Artemis is a member of the metallo-β-lactamase protein family of nucleases. It is essential in vertebrates because, during V(D)J recombination, the RAG complex generates hairpins when it creates the double strand breaks at V, D, and J segments, and Artemis is required to open the hairpins so that th...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chang, Howard H. Y., Watanabe, Go, Lieber, Michael R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591795/
https://ncbi.nlm.nih.gov/pubmed/26276388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.680900
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