Quantification of the Impact of Enzyme-Inducing Antiepileptic Drugs on Irinotecan Pharmacokinetics and SN-38 Exposure

The population pharmacokinetic model reported herein was developed using data from two phase 2 trials of irinotecan for treatment of malignant glioma in order to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics. Patients rece...

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Bibliografiska uppgifter
I publikationen:J Clin Pharmacol
Huvudupphovsmän: Berg, Alexander K., Buckner, Jan C., Galanis, Evanthia, Jaeckle, Kurt A., Ames, Matthew M., Reid, Joel M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591103/
https://ncbi.nlm.nih.gov/pubmed/25975718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.543
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