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Quantification of the Impact of Enzyme-Inducing Antiepileptic Drugs on Irinotecan Pharmacokinetics and SN-38 Exposure
The population pharmacokinetic model reported herein was developed using data from two phase 2 trials of irinotecan for treatment of malignant glioma in order to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics. Patients rece...
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| Publicado no: | J Clin Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591103/ https://ncbi.nlm.nih.gov/pubmed/25975718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.543 |
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