Quantification of the Impact of Enzyme-Inducing Antiepileptic Drugs on Irinotecan Pharmacokinetics and SN-38 Exposure

The population pharmacokinetic model reported herein was developed using data from two phase 2 trials of irinotecan for treatment of malignant glioma in order to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics. Patients rece...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Pharmacol
Egile Nagusiak: Berg, Alexander K., Buckner, Jan C., Galanis, Evanthia, Jaeckle, Kurt A., Ames, Matthew M., Reid, Joel M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591103/
https://ncbi.nlm.nih.gov/pubmed/25975718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.543
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