Determination of irinotecan, SN‐38 and SN‐38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients

BACKGROUND: Irinotecan (CPT‐11) is chemotherapy used mainly in the metastatic colorectal cancer. The purpose of this study was to develop and validate the LC‐MS/MS for the simultaneous determination of CPT‐11, SN‐38, and SN‐38G. METHODS: A 100 μL of plasma was prepared after protein precipitation an...

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Detalhes bibliográficos
Publicado no:J Clin Lab Anal
Main Authors: Atasilp, Chalirmporn, Chansriwong, Pichai, Sirachainan, Ekapob, Reungwetwattana, Thanyanan, Puangpetch, Apichaya, Prommas, Santirhat, Sirilerttrakul, Suwannee, Rerkarmnuaychoke, Budsaba, Wongwaisayawan, Sansanee, Sukasem, Chonlaphat
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817234/
https://ncbi.nlm.nih.gov/pubmed/28393405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcla.22217
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