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Determination of irinotecan, SN‐38 and SN‐38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients
BACKGROUND: Irinotecan (CPT‐11) is chemotherapy used mainly in the metastatic colorectal cancer. The purpose of this study was to develop and validate the LC‐MS/MS for the simultaneous determination of CPT‐11, SN‐38, and SN‐38G. METHODS: A 100 μL of plasma was prepared after protein precipitation an...
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| Publié dans: | J Clin Lab Anal |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6817234/ https://ncbi.nlm.nih.gov/pubmed/28393405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcla.22217 |
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