Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfa...

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Dades bibliogràfiques
Publicat a:J Pharm (Cairo)
Autors principals: Fule, Ritesh A., Meer, Tarique S., Sav, Ajay R., Amin, Purnima D.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590813/
https://ncbi.nlm.nih.gov/pubmed/26555968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/151432
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